HCL ERC DRIVER

Towards complete remission in HCL The team launched a Phase 2 clinical trial in Italy; a similar initiative was then set up by colleagues in the United States, in which late-stage patients who had often undergone chemotherapy repeatedly were treated with tablets of vemurafenib as outpatients for two to four months. Tiacci says the next step is therefore to try to kill residual leukaemic cells to prevent, or at least further delay, relapse. Nanovaccines join the fight against cancer. In light of the results so far, Tiacci predicts it is highly probable that a vemurafenib-based approach to treating HCL will be used clinically within a few years after further testing and regulatory approval: Since first identifying a BRAF mutation known as VE as being involved in HCL development, Tiacci and Falini have focused on how to target the disease with a non-chemotherapy-based, genetics-driven and rationally designed treatment strategy.

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In light of the results so far, Tiacci predicts it is highly probable that a vemurafenib-based approach to treating HCL will be rrc clinically within a few years after further testing and regulatory approval: Since first identifying a BRAF mutation known as VE as being involved in HCL development, Tiacci and Falini have focused on how to target the disease with a non-chemotherapy-based, genetics-driven and rationally designed treatment strategy.

Effective targeted treatment for hairy hck leukaemia.

The team launched a Phase 2 clinical trial in Italy; a similar initiative was then set up by colleagues in the United States, in which late-stage patients who had often undergone chemotherapy repeatedly were treated with tablets of vemurafenib as outpatients for two to four months. Building on the results of their initial trials, the Hairy Cell Leukemia team is now developing a combination therapy in which vemurafenib is egc together with injections of rituximab, an antibody that drives the immune system to attack the hairy cells.

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Effective targeted treatment for hairy cell leukaemia | ERC: European Research Council

Designed to treat melanoma, an hhcl form of skin cancer often carrying the same BRAF mutation, vemurafenib is extremely effective in vitro against HCL, reversing the gene expression that distinguishes HCL cells from the cells of other blood cancers. An ERC-funded project is conducting groundbreaking research into a rare form of leukaemia, proving the effectiveness in patients of non-chemotherapy-based treatments that target the genetic cause of the disease.

However, even patients that showed a complete response had some residual leukaemic cells visible in their bone marrow when tested with highly hcll techniques — a reservoir from which leukaemia can re-grow and cause patients to eventually relapse several months to a few years after being treated.

Its rarity means that it has been the focus of relatively little research since the late s, when chemical compounds called purine analogues were found to be effective in treating it chemotherapeutically, albeit with some severe side effects for patients.

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Tiacci says the next step is therefore to try to kill residual leukaemic cells to prevent, or at least further delay, relapse.

Initial results from an ongoing clinical trial in Italy appear promising.

HCL Infosystems Inaugurates its Enterprise Resource Centre at Puducherry – HCL Infosystems

The results were recently published in the New England Journal of Medicine, a highly respected scientific publication. Towards complete remission in HCL The team launched a Phase 2 clinical trial in Italy; a similar initiative was then set up by colleagues in the United States, edc which late-stage patients who had often undergone chemotherapy repeatedly were treated with tablets of vemurafenib as outpatients for two to four months.

Skip to main content. The drug was not only able to put them into remission, but did so without the toxic effects of chemotherapy, which these patients would not hco withstood. Furthermore, it causes the cells to lose their hair-like protrusions, eventually killing them, the researchers found.

Nanovaccines join the fight against cancer. They turned to a drug called vemurafenib that inhibits BRAF, and which was being developed by pharmaceutical group Roche.